2018

Brazilian Journal of Pharmacognsosy

Rocznik: 2018 | Tom: 28 | Numer: 2

artykuł naukowy

angielski

EN Passiflora caerulea L., P. alata Curtis and P. incarnata L. (synonym for P. edulis Sims), are the most popular representatives of the Passiflora genus in South America. In recent years, a growing attention is paid to the biological activity and phytochemical profiles of crude extracts from various species of Passiflora in worldwide. The aim of this study was to evaluate and to compare of anti-leukemic activity of the dry crude extracts from leaves of three Passiflora species from greenhouse of Poland in two human acute lymphoblastic leukemia cell lines: CCRF-CEM and its multidrug resistant variant. Two systems of liquid chromatography in order to assessment of phytochemical composition of extracts were applied. Extracts of P. alata and P. incarnata showed the potent inhibitory activity against human acute lymphoblastic leukemia CCRF-CEM, while P. caerulea not showed activity (or activity was poor). Despite similarities in quality phytochemical profile of extracts from P. caerulea and P. incarnata, differences in quantity of chemical compounds may determine their various pharmacological potency. For the activity of P. alata extract the highest content of terpenoids and a lack of flavones C-glycosides are believed to be crucial. Summarizing, the crude extract from P. alata leaves may be considered as a substance for complementary therapy for cancer patients. © 2018 Sociedade Brasileira de Farmacognosia

179 - 191

10.1016/j.bjp.2018.01.006

https://www.sciencedirect.com/science/article/pii/S0102695X17306312

CC BY-NC-ND (uznanie autorstwa - użycie niekomercyjne - bez utworów zależnych)

ostateczna wersja opublikowana

03.2018

przed opublikowaniem

15

15