2020

Polyhedron

Rocznik: 2020 | Tom: 180 | Numer: 1

artykuł naukowy

angielski

EN The chemical reaction between cis-[PtCl2(dmso)(2)] and kinetin riboside (KR) or 1-beta-D-ribofuranosyl-4-(2-pyridyl)-1H-1,2,3-triazole (PTR) has resulted in two novel platinum(II) complexes being obtained with different compositions of the coordination sphere: cis-[PtCl2(PTR)] (1) and cis-[PtCl2(dmso)(KR)] (2). Based on multinuclear NMR results (H-1, C-13, N-15, Pt-195), we have demonstrated that the N-donor ligands PTR and KR are able to coordinate to the Pt(II) ion as bidentate via two nitrogen atoms (N(3) and N(7)) or monodentate via only one nitrogen atom (N(7)), respectively. On the other hand, biological studies showed that the novel platinum(II) complexes exhibit different in vitro cytotoxicity towards A549 (lung carcinoma epithelial cells), T24 (urinary bladder cancer cells) and CRL1872 (malignant melanoma cells). The complex cis-[PtCl2(dmso)(KR)] (2) shows in vitro cytotoxicity against T24 and CRL1872 cell lines (the IC50 parameters amount to 52.2 mu M and 21.4 mu M, respectively), whereas cis-[PtCl2(PTR)] (1) is not able to inhibit a proliferation of these cells in the range of tested concentrations. (C) 2020 The Authors. Published by Elsevier Ltd.

114428

10.1016/j.poly.2020.114428

https://www.sciencedirect.com/science/article/pii/S0277538720300851

CC BY-ND (uznanie autorstwa - bez utworów zależnych)

ostateczna wersja opublikowana

02.2020

przed opublikowaniem

100

100