2019

Reaction Kinetics Mechanisms and Catalysis

Rocznik: 2019 | Tom: 127 | Numer: 1

artykuł naukowy

angielski

EN In the presented studies, the effect of hydrogen ions on the stability of the tricyclic aciclovir derivative (i.e. 3,9-dihydro-3-[(2-hydroxyethoxy)methyl]-6-(4-methoxyphenyl)-9-oxo-5H-imidazo[1,2-a]purine; 6-(4-MeOPh)-TACV) and its esters (acetyl (Ac-), iso-butyryl (iBut-), pivaloyl (Piv-), ethoxycarbonyl (Etc-) and nicotinoyl (Nic-)) has been assessed. The HPLC chromatographic method (Lichrospher RP-18 column, 5m, 250mm x 4mm) with UV detection (262nm) was used to observe changes in the concentration of the tested compounds. The mobile phase consisted of acetonitrile-phosphate buffer (pH 6; 20mM; 17mM KH2PO4, 3mM K2HPO4) (35:65, v/v). The studies were carried out in the pH range 0.42-1.38 in the water-organic environment at constant ionic strength (0.50M). The observed rate constants of the degradation reactions of the tested compounds were determined, kinetic equations describing the dependence of k(pH) as a function of pH for the proper acid catalysis were determined and the parameters of the equations describing the reaction of formation the observed product were determined. The dependence of durability on the chemical structure of the tested compounds was indicated and the mechanism of observed reactions was proposed.

283 - 299

10.1007/s11144-019-01553-5

https://link.springer.com/article/10.1007%2Fs11144-019-01553-5

CC BY-NC-SA (uznanie autorstwa - użycie niekomercyjne - na tych samych warunkach)

ostateczna wersja opublikowana

03.2019

przed opublikowaniem

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