2017

Mini-Reviews in Organic Chemistry

Rocznik: 2017 | Tom: 14

artykuł naukowy

angielski

EN Nucleoside triphosphates (NTPs) synthesis has recently been an area of searching for new methods and possible applications in biochemistry and medicine. However, we still lack a universal tool to synthesize NTPs easily and efficiently. For years the most popular method has been the “one-pot, three step” conception by Ludwig with its subsequent improvements which used Yoshikawa’s et al. monophosphorylation method. Further investigation of these reactions has proven many disadvantages: low yields, many byproducts and problems with purification. But they were a starting point for a whole branch of NTPs synthetic methods. Analysis of this evolution process demonstrates some correctness: using a pyrophosphate as a nucleophile and mechanism involving a cyclic intermediates at some stage. What is changing is the idea of phosphorus center activation and the resulting improvements and limita-tions. In this paper we would like to discuss some new achievements in NTPs synthesis considering their role in changing the strategy of phosphorus center activation depending on the needs.

448 - 452

10.2174/1570193x14666170420113635

http://www.eurekaselect.com/node/151774/article/mini-review-of-the-phosphate-center-activation-strategy-in-nucleoside-triphosphate-preparation

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