2020

EBioMedicine

Rocznik: 2020 | Tom: 61

artykuł naukowy

angielski

EN miRNAs are considered important players in oncogenesis, serving either as oncomiRs or suppressormiRs. Although the accumulation of somatic alterations is an intrinsic aspect of cancer development and many important cancer-driving mutations have been identified in protein-coding genes, the area of functional somatic mutations in miRNA genes is heavily understudied. Here, based on analysis of the whole-exome sequencing of over 10,000 cancer/normal sample pairs deposited within the TCGA repository, we identified and characterized over 10,000 somatic mutations in miRNA genes and showed that some of the genes are overmutated in Pan-Cancer and/or specific cancers. Nonrandom occurrence of the identified mutations was confirmed by a strong association of overmutated miRNA genes with KEGG pathways, most of which were related to specific cancer types or cancer-related processes. Additionally, we showed that mutations in some of the overmutated genes correlate with miRNA expression, cancer staging, and patient survival. Our results may also be the first step (form the basis and provide the resources) in the development of computational and/or statistical approaches/tools dedicated to the identification of cancer-driver miRNA genes.

103051

10.1016/j.ebiom.2020.103051

https://api.elsevier.com/content/article/PII:S2352396420304278?httpAccept=text/xml

CC BY-NC-ND (uznanie autorstwa - użycie niekomercyjne - bez utworów zależnych)

ostateczna wersja opublikowana

10.2020

przed opublikowaniem

140

140