2018

RNA Biology

Rocznik: 2018 | Tom: 15 | Numer: 11

artykuł naukowy

angielski

EN MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept. Here, we propose that there is a specific variant of the ceRNA language that takes advantage of simple sequence repeat (SSR) wording. We applied bioinformatics tools to identify human transcripts that may be regarded as repeat-associated ceRNAs (raceRNAs). Multiple protein-coding transcripts, transcribed pseudogenes, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) showing this potential were identified, and numerous miRNAs were predicted to bind to SSRs. We propose that simple repeats expanded in various hereditary neurological diseases may act as sponges for miRNAs containing complementary repeats that would affect raceRNA crosstalk. Based on the representation of specific SSRs in transcripts, expression data for SSR-binding miRNAs and expression profiling data from patients, we determined that raceRNA crosstalk is most likely to be perturbed in the case of myotonic dystrophy type 1 (DM1) and type 2 (DM2).

1399 - 1409

10.1080/15476286.2018.1536593

https://www.tandfonline.com/doi/pdf/10.1080/15476286.2018.1536593

CC BY-NC-ND (uznanie autorstwa - użycie niekomercyjne - bez utworów zależnych)

ostateczna wersja opublikowana

11.2018

w momencie opublikowania

35

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